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Publications

2021


Ruijgrok PV, Ghosh RP, Zemsky S, Nakamura M, Gong R, Ning L, Chen R, Vachharajani VT, Chu AE, Anand N, Eguchi RR, Huang P-S, Lin MZ, Alushin GM, Liphardt JT, and Bryant Z "Optical control of fast and processive engineered myosins in vitro and in living cells." Nat Chem Biol 2021
Pubmed | PDF | Nature Chemical Biology


Zhang R, Redford, S, Ruijgrok PV, Kumar K, Mozaffari A, Zemsky S, Dinner AR, Vitelli V, Bryant Z, Gardel M, and de Pablo JJ "Spatiotemporal control of liquid crystal structure and dynamics through activity patterning." Nat Mater 2021
Pubmed | PDF | Nature Materials


Colen J, Han M, Zhang R, Redford SA, Lemma LM, Morgan L, Ruijgrok PV, Adkins R, Bryant Z, Dogic Z, Gardel ML, de Pablo JJ, Vitelli V "Machine learning active-nematic hydrodynamics." Proc Natl Acad Sci U S A 2021
Pubmed | PDF | PNAS


Galvin CJ, Liu KN, Kennard AS, Tembulkar SH, Dunlap A, Large TAG, Pham T, Le D, Alvarez-Buylla A, Nguyen H, Ponce E, Tran S, Nguyen N, Ngo C, Tran C, Huynh G, Allamandola P, and Bryant Z "Curiosity-based biophysics projects in a high school setting with graduate student mentorship." The Biophysicist 2021
PDF | The Biophysicist

2020


Ivanov IE, Wright AV, Cofsky JC, Aris KDP, Doudna JA, and Bryant Z "Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling." Proc Natl Acad U S A 2020
Pubmed | PDF | PNAS


Hobson MJ, Bryant Z, and Berger JM "Modulated control of DNA supercoiling balance by the DNA-wrapping domain of bacterial gyrase" Nucleic Acids Res 2020
Pubmed | PDF | Nucleic Acids Research


Iino R, Kinbara K, and Bryant Z "Introduction: Molecular motors." Chem Rev 2020
Pubmed | PDF | Editorial

2019


Ivanov IE and Bryant Z "Multi-parameter measurements of conformational dynamics in nucleic acids and nucleoprotein complexes." Methods 2019
Pubmed | PDF | Methods

2018


Acharya BR, Nestor-Bergmann A, Liang X, Gupta S, Duszyc K, Gauquelin E, Gomez GA, Budnar S, Marcq P, Jensen OE, Bryant Z, and Yap AS "A mechanosensitive RhoA pathway that protects epithelia against acute tensile stress." Dev Cell 2018
Pubmed | PDF | Developmental Cell


Basu A, Hobson M, Lebel P, Fernandes LE, Tretter E, Berger JM, and Bryant Z Dynamic coupling between conformations and nucleotide states in DNA gyrase. Nat Chem Biol 2018
Pubmed | PDF | Nature Chemical Biology


Kaplan L, Ierokomos A, Chowdary P, Bryant Z, and Cui B "Rotation of endosomes demonstrates coordination of molecular motors during axonal transport." Sci Adv 2018
Pubmed | PDF | Science Advances


Ivanov IE, Lebel P, Oberstrass FC, Starr CH, Parente AC, Ierokomos A, and Bryant Z "Multimodal measurements of single-molecule dynamics using FluoRBT." Biophys J 2018
Pubmed | PDF | Biophysical Letter


Omabegho T, Gurel PS, Cheng CY, Kim LY, Ruijgrok PV, Das R, Alushin GM, and Bryant Z "Controllable molecular motors engineered from myosin and RNA." Nat Nanotechnol 2018
PubmedPDF | Letter

2017


Gurel PS, Kim LY, Ruijgrok PV, Omabegho T, Bryant Z, and Alushin GM "Cryo-EM structures reveal specialization at the myosin VI-actin interface and a mechanism of force sensitivity." eLife 2017
Pubmed | eLife

2016


Basu A, Parente AC, and Bryant Z "Structural dynamics and mechanochemical coupling in DNA gyrase." J Mol Biol 2016
Pubmed | PDF | Journal of Molecular Biology

2014


Nakamura M, Chen L, Howes SC, Schindler TD, Nogales E, and Bryant Z “Remote control of myosin and kinesin motors using light-activated gearshifting.” Nat Nanotechnol 2014
PubmedPDF | News and Views


Lebel P, Basu A, Oberstrass FC, Tretter EM, and Bryant Z "Gold rotor bead tracking for high-speed measurements of DNA twist, torque, and extension." Nat Methods 2014
Pubmed | PDFNature Methods 


Schindler TD, Chen L, Lebel P, Nakamura M, and Bryant Z "Engineering myosins for long-range transport on actin filaments." Nat Nanotechnol 2014
Pubmed | PDF | Editorial | News and Views

2013


Cipriano DJ, Jung J, Vivona S, Fenn TD, Brunger AT, and Bryant Z "Processive ATP-driven substrate disassembly by the N-ethylmaleimide-sensitive factor (NSF) molecular machine." J Biol Chem 2013
Pubmed | PDF | Journal of Biological Chemistry


Oberstrass FC, Fernandes LE, Lebel P, and Bryant Z "Torque spectroscopy of DNA: Base-pair stability, boundary effects, backbending, and breathing dynamics." Phys Rev Lett 2013
PubmedPDF | Physics Highlight

2012


Bryant Z, Oberstrass FC, and Basu A "Recent developments in single-molecule DNA mechanics." Curr Opin Struct Biol 2012
Pubmed | PDFCurrent Opinion in Structural Biology


Basu A, Schoeffler AJ, Berger JM, and Bryant Z "ATP binding controls distinct structural transitions of E. Coli DNA gyrase in complex with DNA." Nat Struct Mol Biol 2012
Pubmed | PDFCoverNature Structural and Molecular Biology


Oberstrass FC, Fernandes LE, and Bryant Z "Torque measurements reveal sequence-specific structural transitions in supercoiled DNA." Proc Natl Acad Sci USA 2012
Pubmed | PDFPNAS


Chen L, Nakamura M, Schindler TD, Parker D, and Bryant Z "Engineering controllable bidirectional molecular motors based on myosin." Nat Nanotechnol 2012
Pubmed | PDF | News and Views

2011


Elting MW, Bryant Z, Liao J-C, and Spudich JA "Detailed tuning of structure and intramolecular communication are dispensable for processive motion of myosin VI." Biophys J 2011
Pubmed | PDFBiophysical Journal

2010


Dunn AR, Chuan P, Bryant Z, and Spudich JA "Contribution of the myosin VI tail domain to processive stepping and intramolecular tension sensing." Proc Natl Acad Sci USA 2010
Pubmed | PDFPNAS

2009


Parker D, Bryant Z, and Delp S "Coarse-grained structural modeling of molecular motors using multibody dynamics." Cell Mol Bioeng 2009
Pubmed | PDFCellular and Molecular Bioengineering


Liao JC, Elting MW, Spudich JA, and Bryant Z "Engineered myosin VI motors reveal minimal structural determinants of directionality and processivity." J Mol Biol 2009
Pubmed | PDFCommunication

2007


Nöllmann M, Stone MD, Bryant Z, Gore J, Crisona NJ, Hong SC, Mitelheiser S, Maxwell A, Bustamante C, and Cozzarelli NR "Multiple modes of Escherichia coli DNA gyrase activity revealed by force and torque." Nat Struct Mol Biol 2007
Pubmed | PDFNature Structural and Molecular Biology


Bryant Z, Altman D, and Spudich JA "The power stroke of myosin VI and the basis of reverse directionality." Proc Natl Acad Sci U S A 2007
Pubmed | PDFPNAS

2006


Gore J, Bryant Z, Nöllmann M, Le MU, Cozzarelli NR, and Bustamante C "DNA overwinds when stretched." Nature 2006
Pubmed | PDFLetter


Gore J, Bryant Z, Stone MD, Nöllmann M, Cozzarelli NR, and Bustamante C "Mechanochemical analysis of DNA gyrase using rotor bead tracking." Nature 2006
Pubmed | PDFLetter

2003


Bryant Z, Stone MD, Gore J, Smith SB, Cozzarelli NR, and Bustamante C "Structural transitions and elasticity from torque measurements on DNA." Nature 2003
Pubmed | PDFLetter


Stone MD, Bryant Z, Crisona NJ, Smith SB, Vologodskii A, Bustamante C, and Cozzarelli NR "Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases." Proc Natl Acad Sci U S A 2003
Pubmed | PDFPNAS


Bustamante C, Bryant Z, and Smith SB "Ten years of tension: single-molecule DNA mechanics." Nature 2003
Pubmed | PDFFeature

2000


Bryant Z, Pande VS, and Rokhsar DS "Mechanical unfolding of a beta-hairpin using molecular dynamics." Biophys J 2000
Pubmed | PDFBiophysical Journal

1999


Bryant Z, Subrahmanyan L, Tworoger M, LaTray L, Liu CR, Li MJ, van den Engh G, and Ruohola-Baker H "Characterization of differentially expressed genes in purified Drosophila follicle cells: toward a general strategy for cell type-specific developmental analysis." Proc Natl Acad Sci U S A 1999
Pubmed | PDFPNAS


Tworoger M, Larkin MK, Bryant Z, and Ruohola-Baker H "Mosaic analysis in the drosophila ovary reveals a common hedgehog-inducible precursor stage for stalk and polar cells." Genetics 1999
Pubmed | PDF

1997


Clegg NJ, Frost DM, Larkin MK, Subrahmanyan L, Bryant Z, and Ruohola-Baker H "maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA." Development 1997
Pubmed | PDF